Sinus arrest during treatment with amiodarone.

effect shown in highly selected subgroups of patients cannot, however, be extrapolated to other groups of patients, although other studies, including those with a wider, less selected population,9 12 indicate that even low-risk patients may profit from long-term beta-adrenoceptor blockade. There has been much debate about analysis, presentation, and interpretation of beta-blocker post-infarction trials. We have presented our data so that end-point differences based on both the "intention-to-treat" and "in-trial" differences can be calculated, but we have chosen to analyse the results according to intention to treat. We hope that our results will make a small contribution to an important debate. This study was made possible by generous grants from the Norwegian Council for Cardiovascular Diseases and the National Centre for Medical Products Control. We also thank Imperial Chemical Industries Ltd, who provided the test tablets for the study, and ICI-Pharma, Norway, especially Mr Tore Ekeli, and the pharmaceutical staff, nurses, and doctors for all participating hospitals for their advice, patience, and invaluable help throughout the trial. References Pell S, d'Allonzo CA. Immediate and five-year survival of employed men with a first myocardial infarction.